OpenCRAVAT

Discover which OpenCRAVAT annotators are being run (a curated default set)

Inspect annotator output schemas (field names/types/descriptions)

Annotate variants by genomic coordinates (chrom/pos/ref/alt). Accepts only GRCh38/hg38 coordinates

Annotate variants by dbSNP rsID

Annotate variants by ClinGen Allele Registry ID (CAid)

Annotate variants by HGVS notation (g./c./p.)

Convert a protein missense notation (e.g., BRAF V600E) into candidate GRCh38 genomic HGVS changes (via SynVar), which you can then pass to HGVS annotation